Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Abstract
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.
- Publication:
-
Scientific Reports
- Pub Date:
- September 2017
- DOI:
- 10.1038/s41598-017-10993-9
- Bibcode:
- 2017NatSR...710669S