Cryptic bioactivity capacitated by synthetic hybrid plant peptides
Abstract
Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.
- Publication:
-
Nature Communications
- Pub Date:
- February 2017
- DOI:
- 10.1038/ncomms14318
- Bibcode:
- 2017NatCo...814318H