In 1970, Kobayashi conjectured that general hypersurfaces of sufficiently large degree in $P^n$ are hyperbolic. In this paper we prove that a general sufficiently ample hypersurface in a smooth projective variety is hyperbolic. To prove this statement, we construct hypersurfaces satisfying a property which is Zariski open and which implies hyperbolicity. These hypersurfaces are chosen such that the geometry of their higher order jet spaces can be related to the geometry of a universal family of complete intersections. To do so, we introduce a Wronskian construction which associates a (twisted) jet differential to every finite family of global sections of a line bundle.