How social structures, space, and behaviors shape the spread of infectious diseases using chikungunya as a case study
Abstract
Although the determinants of infectious disease transmission have been extensively investigated in small social structures such as households or schools, the impact of the wider environment (e.g., neighborhood) on transmission has received less attention. Here we use an outbreak of chikungunya as a case study where detailed epidemiological data were collected and combine it with statistical approaches to characterize the multiple factors that influence the risk of infectious disease transmission and may depend on characteristics of the individual (e.g., age, sex), of his or her close relatives (e.g., household members), or of the wider neighborhood. Our findings highlight the role that integrating statistical approaches with in-depth information on the at-risk population can have on understanding pathogen spread.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- November 2016
- DOI:
- 10.1073/pnas.1611391113
- Bibcode:
- 2016PNAS..11313420S