Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency
Abstract
It is well known that because of constant metabolic flow and interconnectivity, alteration of any one step in lipid metabolism can lead to changes in many lipid metabolites. Therefore, the exact metabolites causing lipid metabolic diseases are often elusive. By creating a new genetic model, we uncoupled the changes of long-chain bases and ceramide that are caused by ceramide synthase 1 deficiency. This work sheds light on the neurotoxicity of sphingolipid precursors, the long-chain bases, in neurodegenerative diseases.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- May 2016
- DOI:
- 10.1073/pnas.1522071113
- Bibcode:
- 2016PNAS..113.5928S