Human autoreactive T cells recognize CD1b and phospholipids
Abstract
Peptides are known to be targets of autoreactive T cells that can cause autoimmune diseases. Here we show that human T cells recognize self-lipids displayed on the surface of cells by CD1b proteins. A particular lipid that is recognized by CD1b autoreactive cells, phosphatidylglycerol, is present in mammalian mitochondria and in bacteria. Therefore, these data define a phospholipid autoantigen that is released during mitochondrial stress and bacterial infection.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- January 2016
- DOI:
- 10.1073/pnas.1520947112
- Bibcode:
- 2016PNAS..113..380V