Null allele mutants of trt-1, the catalytic subunit of telomerase in Caenorhabditis elegans, are less sensitive to Mn-induced toxicity and DAergic degeneration
Abstract
Telomerase reverse transcriptase (trt-1) is the catalytic subunit of telomerase in Caenorhabditis elegans (C. elegans). Manganese affects survival of C. elegans and compromises integrity of the dopaminergic (DAergic) system in wt worms. Null allele mutation in trt-1 does not exacerbate Mn-induced toxicity, but improves survival, and attenuates injury to the DAergic system.
- Publication:
-
NeuroToxicology
- Pub Date:
- December 2016
- DOI:
- 10.1016/j.neuro.2016.08.016
- Bibcode:
- 2016NeuTx..57...54I
- Keywords:
-
- Manganese;
- Telomerase;
- trt-1;
- C. elegans;
- DAergic degeneration