Biological evaluation of certain substituted hydantoins and benzalhydantoins against microbes
Abstract
Twenty-three synthetic (thio)hydantoins and benzalhydantoins were evaluated for antimicrobial activity against Candida albicans, Malassezia furfur, Escherichia coli and Staphylococcus aureus, by the paper disc diffusion method. 3-n-butyl-4'-nitrobenzalhydantoin showed very high activity against E. coli and high selectivity with respect to the other microorganisms, while 3-n-butyl-2'-bromo-4',5'-dimethoxybenzal hydantoin demonstrated very high selectivity in its activity against M. furfur and S. aureus. These compounds show the most promise as drug lead compounds.
- Publication:
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Materials Science and Engineering Conference Series
- Pub Date:
- February 2016
- DOI:
- 10.1088/1757-899X/107/1/012058
- Bibcode:
- 2016MS&E..107a2058H