Stability of underdominant genetic polymorphisms in population networks
Abstract
Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been given to underdominance within a single population and the maintenance of genetic differences between two populations exchanging migrants. Here we explore the dynamics of an underdominant system in a network of multiple discrete, yet interconnected, populations. Stability of genetic differences in response to increases in migration in various topological networks is assessed. The network topology can have a dominant and occasionally non-intuitive influence on the genetic stability of the system.
- Publication:
-
Journal of Theoretical Biology
- Pub Date:
- February 2016
- DOI:
- 10.1016/j.jtbi.2015.11.023
- arXiv:
- arXiv:1509.02205
- Bibcode:
- 2016JThBi.390..156L
- Keywords:
-
- Underdominance;
- Coordination game;
- Network topology;
- Dynamical system;
- Population genetics;
- Quantitative Biology - Populations and Evolution