Structural basis for acyl-group discrimination by human Gcn5L2
Abstract
Structures of human Gcn5L2 bound to propionyl-CoA and butyryl-CoA show how the active site accommodates different acyl modifications and explain why butyryl-CoA acts as a competitive inhibitor.
- Publication:
-
Acta Crystallographica Section D
- Pub Date:
- June 2016
- DOI:
- 10.1107/S2059798316007907
- Bibcode:
- 2016AcCrD..72..841R
- Keywords:
-
- histone acetyltransferase;
- acyltransferase;
- propionyl-CoA;
- butyryl-CoA;
- Gcn5