NAD+ in aging, metabolism, and neurodegeneration
Abstract
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD+ concentrations change during aging, and modulation of NAD+ usage or production can prolong both health span and life span. Here we review factors that regulate NAD+ and discuss how supplementation with NAD+ precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.
- Publication:
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Science
- Pub Date:
- December 2015
- DOI:
- 10.1126/science.aac4854
- Bibcode:
- 2015Sci...350.1208V
- Keywords:
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- PHYSIOLOGY