Chronic centrosome amplification without tumorigenesis
Abstract
Centrosomes organize the microtubule cytoskeleton in interphase and mitosis. During mitosis, the centrosomes are important for the formation and positioning of the bipolar mitotic spindle on which chromosomes are segregated. The presence of more than two centrosomes can drive mitotic chromosome segregation errors and the formation of aneuploid cells. Centrosome amplification is a common feature of aneuploid cancer cells, but a long-standing question is whether this is a cause or a consequence of tumor development. To assess this question, we generated mice in which centrosome amplification can be induced widely. Despite chronic centrosome amplification, tumorigenesis was not enhanced, demonstrating that an excess of centrosomes is not sufficient to drive tumor development.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- November 2015
- DOI:
- 10.1073/pnas.1519388112
- Bibcode:
- 2015PNAS..112E6321V