A role for the mevalonate pathway in early plant symbiotic signaling
Abstract
Metabolites of the mevalonate (MVA) pathway play essential roles in the regulation of growth and development in many organisms. In this study, we demonstrate that a key regulatory enzyme of the MVA pathway is directly involved in the signaling pathway that transduces endosymbiotic microbial signals in Medicago truncatula. Furthermore, we show that exogenous MVA application is sufficient to activate this transduction pathway. The use of mutants in the signaling pathway and a heterologous expression system provides evidence that the MVA pathway is a missing link between the initial perception of microbial signals at the host plasma membrane and the regulation of symbiotic gene expression in the nucleus.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- August 2015
- DOI:
- 10.1073/pnas.1413762112
- Bibcode:
- 2015PNAS..112.9781V