Systematic identification of signal integration by protein kinase A
Abstract
Protein kinase A (PKA) complexes are versatile signaling enzymes controlling homeostasis in eukaryotes. This enzyme is involved in multiple functions under physiological and pathological conditions in humans and governs the virulence of many pathogenic fungi. Here we systematically identify PKA regulators in yeast. Notably, we describe signaling to PKA that involves feedback from the cellular recycling process, autophagy. We also uncover a posttranslational modification, acetylation, that regulates PKA activity in both yeast and mammals, and we show that this mechanism impacts aging. Thus, we identify what regulates PKA as a first step toward the ability to cure diseases and infections, for instance, by providing new candidate genes for drug targeting in health research and antifungals for agricultural and medical purposes.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- April 2015
- DOI:
- 10.1073/pnas.1409938112
- Bibcode:
- 2015PNAS..112.4501F