Analysis of gene-environment interactions in postnatal development of the mammalian intestine
Abstract
The mammalian intestine provides a key interface with several essential environmental factors, including nutrients, toxins, resident microbiota, and pathogens. Consequently, the intestine undergoes major developmental transitions that correspond to dramatic changes in the environment: one at birth and the other at weaning. These transitions reflect both developmental and environmentally induced changes in intestinal gene expression. Here, we performed a systematic analysis of global gene expression that is associated with developmental timing versus the changes that are due to the innate immune signaling pathways mediated by toll-like receptor (TLR) and IL-1 receptor families. The results reveal distinct roles of these pathways in intestinal adaptation throughout postnatal development.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 2015
- DOI:
- 10.1073/pnas.1424886112
- Bibcode:
- 2015PNAS..112.1929R