Evolutionary pattern in the OXT-OXTR system in primates: Coevolution and positive selection footprints: Fig. 1.
Abstract
It was previously believed that placental mammals present no variability in oxytocin (OXT). The present study reports novel data on the diversity of OXT and its receptor (OXTR) in primate species, including New World monkeys. Contrary to prior expectations, we found three novel OXT forms and several OXTR nonsynonymous changes not previously described. In the Cebidae family, signals of positive selection were found for an OXT variant at position 8, which is associated with larger litter sizes. We detected positive selection for OXTR forms and report a coevolutionary process between changes in OXT and OXTR.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- January 2015
- DOI:
- 10.1073/pnas.1419399112
- Bibcode:
- 2015PNAS..112...88V