Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2
Abstract
HDAC1 and HDAC2 co-localize with UV radiation-induced DNA damage sites. HDAC1 translocation to chromatin is dependent on DDB2 function. HDAC1 and HDAC2 are involved in H3K56Ac deacetylation. H3K56Ac deacetylation requires DDB1 and DDB2 but not XPA or XPC functions. HDAC1/2 depletion decreases XPC ubiquitination and local γH2AX accumulation.
- Publication:
-
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Pub Date:
- June 2015
- DOI:
- Bibcode:
- 2015MRFMM.776...16Z
- Keywords:
-
- Histone post-translational modifications;
- Nucleotide excision repair;
- Damaged DNA-binding protein 2;
- Histone deacetylases;
- Acetylated histone H3 lysine 56;
- Xeroderma pigmentosum group E