We present a new method for exploring cancer gene expression data based on tools from algebraic topology. Our method selects a small relevant subset from tens of thousands of genes while simultaneously identifying nontrivial higher order topological features, i.e., holes, in the data. We first circumvent the problem of high dimensionality by dualizing the data, i.e., by studying genes as points in the sample space. Then we select a small subset of the genes as landmarks to construct topological structures that capture persistent, i.e., topologically significant, features of the data set in its first homology group. Furthermore, we demonstrate that many members of these loops have been implicated for cancer biogenesis in scientific literature. We illustrate our method on five different data sets belonging to brain, breast, leukemia, and ovarian cancers.
- Pub Date:
- October 2014
- Quantitative Biology - Genomics;
- Computer Science - Computational Geometry;
- Mathematics - Algebraic Topology;
- Quantitative Biology - Quantitative Methods
- 12 pages, 9 figures, appears in proceedings of Pacific Symposium on Biocomputing 2015