A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells
Abstract
CD8 tissue-resident memory T (TRM) cells provide efficient local control of viral infection, but the role of CD4 TRM is less clear. Here, by using parabiotic mice, we show that a preexisting pool of CD4 TRM cells in the genital mucosa was required for full protection from a lethal herpes simplex virus 2 (HSV-2) infection. Chemokines secreted by a local network of macrophages maintained vaginal CD4 TRM in memory lymphocyte clusters (MLCs), independently of circulating memory T cells. CD4 TRM cells within the MLCs were enriched in clones that expanded in response to HSV-2. Our results highlight the need for vaccine strategies that enable establishment of TRM cells for protection from a sexually transmitted virus and provide insights as to how such a pool might be established.
- Publication:
-
Science
- Pub Date:
- October 2014
- DOI:
- 10.1126/science.1257530
- Bibcode:
- 2014Sci...346...93I
- Keywords:
-
- IMMUNOLOGY