Exposure to common quaternary ammonium disinfectants decreases fertility in mice
Abstract
Tested the reproductive toxicity of a common disinfectant used in many commercial and residential products. Disinfectant contained the active ingredients: alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC). Mouse breeding pairs were dosed with ADBAC+DDAC at 0, 60 or 120mg/kg/day in the feed for 6 months. Long term exposure decreased fertility and fecundity and caused dam mortality in a dose dependent manner. This study highlights the importance of testing the toxicity of mixtures over individual compounds.
- Publication:
-
Reproductive Toxicology
- Pub Date:
- December 2014
- DOI:
- Bibcode:
- 2014RepTx..50..163M
- Keywords:
-
- QAC;
- quaternary ammonium compound;
- ADBAC;
- alkyl dimethyl benzyl ammonium chloride;
- DDAC;
- didecyl dimethyl ammonium chloride;
- DDA;
- dimethyl didecyl ammonium;
- HWS-256;
- disinfectant mixture of alkyl (60% C14;
- 25% C12;
- 15% C16) dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC);
- GC–MS;
- gas chromatography–mass spectrometry;
- HPLC;
- high-performance liquid chromatography;
- LC–MS;
- liquid chromatography–mass spectrometry;
- CWRU;
- Case Western Reserve University;
- WSU;
- Washington State University;
- VPI;
- Virginia Polytechnic Institute and State University;
- Quaternary ammonium compounds;
- Reproductive toxicity;
- Toxicology;
- Fertility;
- Fecundity