We present new geomorphic, stratigraphic, and chronologic data for Holocene glacier fluctuations in the Lago Argentino basin on the eastern side of the southern Patagonian Andes. Chronologic control is based on 14C and surface-exposure 10Be dating. After the Lateglacial maximum at 13,000 cal yrs BP, the large ice lobes that filled the eastern reaches of Lago Argentino retreated and separated into individual outlet glaciers; this recession was interrupted only by a stillstand or minor readvance at 12,200 cal yrs BP. The eight largest of these individual outlet glaciers are, from north to south: Upsala, Agassiz, Onelli, Spegazzini, Mayo, Ameghino, Perito Moreno, and Grande (formerly Frías). Holocene recession of Upsala Glacier exposed Brazo Cristina more than 10,115 ± 100 cal yrs BP, and reached inboard of the Holocene moraines in Agassiz Este Valley by 9205 ± 85 cal yrs BP; ice remained in an inboard position until 7730 ± 50 cal yrs BP. Several subsequent glacier readvances are well documented for the Upsala and Frías glaciers. The Upsala Glacier readvanced at least seven times, the first being a relatively minor expansion - documented only in stratigraphic sections - between 7730 ± 50 and 7210 ± 45 cal yrs BP. The most extensive Holocene advances of Upsala Glacier resulted in the deposition of the Pearson 1 moraines and related landforms, which are divided into three systems. The Pearson 1a advance occurred about 6000-5000 cal yrs BP and was followed by the slightly less-extensive Pearson 1b and 1c advances dated to 2500-2000 and 1500-1100 cal yrs BP, respectively. Subsequent advances of Upsala Glacier resulted in deposition of the Pearson 2 moraines and corresponding landforms, also separated into three systems, Pearson 2a, 2b, and 2c, constructed respectively at ̃700, >400, and <300 cal yrs BP to the early 20th century. Similar advances are also recorded by moraine systems in front of Grande Glacier and herein separated into the Frías 1 and Frías 2a, 2b, and 2c. The Onelli and Ameghino glacier valleys also preserve older Holocene moraines. In the Agassiz, Spegazzini, and Mayo valleys, ice of the late-Holocene advances appears to have overridden landforms equivalent in age to Pearson 1. Perito Moreno Glacier is an extreme case in which ice of historical (Pearson 2c) advances overrode all older Holocene moraines. Based on the distribution and number of moraines preserved, we infer that the response to climate differed among the Lago Argentino outlet glaciers during the Holocene. This led us to examine the effects of climatic and non-climatic factors on individual glaciers. As a consequence, we detected an important effect of the valley geometry (hypsometry) on the timing and magnitude of glacier response to climate change. These results indicate that caution is needed in correlating moraines among glacier forefields without firm morpho-stratigraphic and age control. Finally, we note important similarities and differences between the overall moraine chronology in the Lago Argentino basin and that in other areas of southern South America and elsewhere in the Southern Hemisphere.