PNAS Plus: From the Cover: Dietary history contributes to enterotype-like clustering and functional metagenomic content in the intestinal microbiome of wild mice
Abstract
Recent investigation of several mammalian hosts suggests that their intestinal bacterial communities display evidence of clusters characterized by differences in specific bacterial taxa, a concept referred to as enterotypes. By performing stable isotope analysis of environmental samples, monitoring communities during dietary shifts, and collecting functional metagenomic sequence data, we provide novel insight into the origins and dynamics of enterotype-like community clustering in wild house mice. Two clusters are present in wild mice, one associated with higher plant-derived and another with animal-derived food intake, which can shift within a period of 1 wk. Remarkably, these clusters display shared characteristics with those present in humans, chimpanzees, and laboratory mice, suggesting ancient shared traits among mammalian bacterial communities.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- July 2014
- DOI:
- 10.1073/pnas.1402342111
- Bibcode:
- 2014PNAS..111E2703W