Crumbs promotes expanded recognition and degradation by the SCFSlimb/β-TrCP ubiquitin ligase
Abstract
Regulation of tissue growth is essential for metazoan development and adult homeostasis. The Hippo (Hpo) pathway is an evolutionarily conserved signaling cascade that has emerged as a crucial regulator of tissue size by virtue of its control of cell proliferation and cell death. Multiple epithelial architecture inputs converge on Hpo signaling, allowing tissues to quickly respond to disruptions in cell-cell and cell-matrix interactions. Here, we show that the polarity protein Crumbs promotes the apical localization and degradation of the Hpo pathway protein Expanded, by the SCFSlmb/β-TRCP ubiquitin ligase. This ubiquitin-dependent mechanism could potentially allow the dynamic regulation of Hpo signaling in response to changes in polarity.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- May 2014
- DOI:
- 10.1073/pnas.1315508111
- Bibcode:
- 2014PNAS..111E1980R