Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma
Abstract
It is suggested that regulation of metabolism is a point of convergence of many different cancer-associated pathways. Here we challenged the validity of this assertion and verified that a transversal metabolic signature in cancer emerges chiefly in the regulation of nucleotide metabolism. However, the most common form of renal cancer deviates from this behavior and presents some defects in its metabolic network not present in the normal kidney and unseen in other tumors. Notably, reduced copy number in key metabolic genes located adjacent to VHL (a tumor suppressor gene frequently deleted in this cancer) recapitulates these defects. These results are suggestive that recurrent chromosomal loss of heterozygosity in cancer may uniquely shape the metabolic network.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 2014
- DOI:
- 10.1073/pnas.1319196111
- Bibcode:
- 2014PNAS..111E.866G