Osteopontin expression by CD103− dendritic cells drives intestinal inflammation
Abstract
Dendritic cells (DCs) are important for the development of intestinal inflammation in humans with inflammatory bowel disease (IBD) and in mice with experimental colitis. We demonstrate that a subset of DCs, CD103- DCs, isolated from murine mesenteric lymph nodes, is highly pathogenic for murine intestinal inflammation and expresses high levels of the cytokine osteopontin (Opn). This Opn expression by CD103- DCs is crucial for their pathogenicity. We define a specific domain of Opn protein significant for inducing pathogenic properties in CD103- DCs. Blockade of the interaction of this Opn domain with integrin α9 expressed on CD103- DCs abrogated their harmful effects. These findings may open new paths in IBD treatment.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- March 2014
- DOI:
- 10.1073/pnas.1316447111
- Bibcode:
- 2014PNAS..111E.856K