Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis
Abstract
New effective therapies are desperately needed for lung cancer because most current lung cancer treatments rarely prevent the metastatic disease that causes the majority of patient deaths. We discovered that the neurotrophin receptor TrkB is an important therapeutic target in metastatic lung cancer using a combination of cell line assays, conditional mouse models, and patient samples.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- July 2014
- DOI:
- 10.1073/pnas.1404399111
- Bibcode:
- 2014PNAS..11110299S