Regulation of cell wall growth is a process of fundamental importance in cell biology. In this paper, to our knowledge, we demonstrate for the first time that mechanical stress directly influences cell wall synthesis of bacteria. In a series of simple experiments, we elastically and plastically deform cell walls as they grow by applying anisotropic mechanical stresses to bacteria. Using a theory of dislocation-mediated growth, we explain how growth and form of the cell walls are quantitatively related to one another in bacteria.
Proceedings of the National Academy of Science
- Pub Date:
- April 2014
- Condensed Matter - Soft Condensed Matter;
- Physics - Biological Physics;
- Quantitative Biology - Cell Behavior
- PNAS 111 16 5778-5783 (2014)