Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients
Abstract
Hematopoietic stem and progenitor cells (HSPCs) cannot only replace depleted progeny pools, but act as the primary immune response to various pathological conditions. Here we show that the circulating HSPCs from various patients with solid tumors exhibit a generalized myeloid bias with a skew toward granulocytic differentiation. Importantly, circulating hematopoietic precursors were highly enriched in tumor tissues and positively correlated with disease progression. We developed an in vitro short-term culture model to effectively induce the rapid generation of myeloid-derived suppressor cells (MDSCs), defined as cord blood-derived MDSCs. In addition, we suggest that the altered circulating HSPCs may serve as an important link between dysregulated hematopoiesis and accumulated immunosuppressive MDSCs in patients with cancer.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- March 2014
- DOI:
- 10.1073/pnas.1320753111
- Bibcode:
- 2014PNAS..111.4221W