PIKE is essential for oligodendroglia development and CNS myelination
Abstract
Accumulation of a lipid-rich substance (myelin sheath) around the axon of neurons enables the nerve cells to transmit information faster. However, the molecular mechanism that controls this important process is not well understood. Here, we report that the GTPase phosphoinositide 3-kinase enhancer is a regulator of myelin sheath formation during development and myelin repair.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 2014
- DOI:
- 10.1073/pnas.1318185111
- Bibcode:
- 2014PNAS..111.1993C