Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons
Abstract
Dendrites are highly polarized structures that are important for synaptic input and signal integration. However, the molecular and cellular mechanism underlying the polarized dendrite development in vivo remains largely unknown. This report shows that LKB1, a serine-threonine protein kinase known to be involved in axon formation in embryonic cortical pyramidal neurons, is essential for the polarized initiation and oriented extension of the primary dendrite in adult-born hippocampal granule cells, and provides further evidence that this morphogenic effect of LKB1 is mediated via regulation of polarized distribution of Golgi apparatus. These findings not only add a unique function to the growing list of LKB1 cellular actions, but also provide new clues to the subcellular mechanism of LKB1's action.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- January 2014
- DOI:
- 10.1073/pnas.1321454111
- Bibcode:
- 2014PNAS..111..469H