Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
Abstract
T cells recognize fragments of cellular peptides when presented at the cell surface by HLA molecules. Knowledge of which peptides derived from cellular proteins that are available at the cell surface for T-cell recognition is central to our understanding of T-cell tolerance and immunity. Here, we used alloreactive T cells as tools for detection of self-peptides bound to foreign HLA-A2. Our results indicate that the self-immunopeptidome is far more diverse than previously estimated. Furthermore, our data demonstrate that such self-peptides represent highly attractive targets for T-cell-based cancer immunotherapy.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- January 2014
- DOI:
- 10.1073/pnas.1306549111
- Bibcode:
- 2014PNAS..111..403K