Assessing the mechanism of DNA damage induced by lead through direct and indirect interactions
Abstract
Direct and indirect interactions between lead and DNA were discussed. Lead induced a dose-dependent increase in the frequency of DNA strand breaks. Pb2+ could bind to DNA by minor groove binding effects and electrostatic forces. Suggestions on the DNA damage induced by heavy metal pollutants were provided.
- Publication:
-
Journal of Photochemistry and Photobiology B: Biology
- Pub Date:
- July 2014
- DOI:
- 10.1016/j.jphotobiol.2014.04.020
- Bibcode:
- 2014JPPB..136...46Z
- Keywords:
-
- Lead genotoxicity;
- Comet assay;
- DNA–protein crosslinks;
- Isothermal titration calorimetry;
- Binding mode