Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells
Abstract
A fundamental question in immunology is how the coordination of immune signals and metabolic programs regulates immune responses. The identification of metabolic pathways orchestrating the activation of lymphocytes and dendritic cells (DCs) has advanced our understanding of immune activation, but whether cell metabolism contributes to development of immune cells is unknown. Here we have genetically defined a crucial metabolic checkpoint for DC development that is mediated by the interplay between Tsc1-mTOR complex 1 signaling and Myc-dependent bioenergetic and biosynthetic programs. Dysregulation of this pathway impairs survival, proliferation, and functional differentiation of DCs, thereby highlighting the importance of metabolic programming of DC development.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 2013
- DOI:
- 10.1073/pnas.1308905110
- Bibcode:
- 2013PNAS..110E4894W