ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer
Abstract
Although locally invasive prostate cancer is nearly always curable, metastatic prostate cancer usually results in lethality. Our study investigates the temporal progression and molecular mechanisms underlying prostate cancer metastasis using a new genetically engineered mouse model. Using lineage-tracing analyses, we show that dissemination of tumor cells occurs early in cancer progression, and well before the occurrence of metastases. We further show that metastasis is temporally coincident with expression of the oncogenic ETS gene Etv4, and that Etv4 promotes prostate cancer metastasis in vivo. Our findings suggest that Etv4 may be a target for therapeutic intervention in metastatic prostate cancer.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- September 2013
- DOI:
- 10.1073/pnas.1303558110
- Bibcode:
- 2013PNAS..110E3506A