Inhibition of pluripotent stem cell-derived teratoma formation by small molecules
Abstract
We found that quercetin/YM155-induced selective cell death is sufficient to completely inhibit teratoma formation after transplantation of human pluripotent stem cell (hPSC)-derived cells. These data provide the first "proof of concept" that small-molecule targeting of hPSC-specific antiapoptotic pathway(s) is a viable strategy to prevent tumor formation by selectively eliminating remaining undifferentiated pluripotent cells for safe hPSC-based therapy.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- August 2013
- DOI:
- 10.1073/pnas.1303669110
- Bibcode:
- 2013PNAS..110E3281L