Phosphodiesterase-8A binds to and regulates Raf-1 kinase
Abstract
The ERK pathway is a ubiquitous mechanism for transducing a variety of extracellular signals into intracellular events. It also is misregulated in a number of different disease states including several cancers. The ERK pathway crosstalks with other signaling cascades, including the cAMP system. In this paper, we show that a key component of the ERK pathway, Raf-1 kinase, can associate with a specific cyclic nucleotide phosphodiesterase, phosphodiesterase 8A (PDE8A), to modulate the activity of the kinase. We report that the interaction between Raf-1 and PDE8A underpins functional consequences of ERK signaling in several different model systems.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- April 2013
- DOI:
- 10.1073/pnas.1303004110
- Bibcode:
- 2013PNAS..110E1533B