Epstein-Barr virus nuclear antigen leader protein localizes to promoters and enhancers with cell transcription factors and EBNA2
Abstract
Epstein-Barr virus nuclear antigen (EBNA) leader protein (LP) and EBNA2 (E2) up-regulation of virus and cell gene expression is important for human B-lymphocyte conversion to continuous, potentially malignant, lymphoblast cell lines. Although the molecular mechanism(s) underlying LP and E2 regulation of cell gene expression have been partially elucidated, LP ChIP-sequencing studies have now revealed that LP and LP/E2 interact, genome-wide, with human B-cell transcription factors, mostly at or near prepatterned promoter sites, to increase cell transcription factor occupancies, increase activation-associated histone marks, and positively affect cell gene transcription.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- November 2013
- DOI:
- 10.1073/pnas.1317608110
- Bibcode:
- 2013PNAS..11018537P