Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice
Abstract
We present a unique study of a liver-induced systemic tolerance using an intact virus, other than a single protein component-induced liver-persistent model. Liver-educated regulatory cells migrate into peripheral sites and mediate the systemic tolerance. Kupffer cells induce the generation of type 1-like regulatory cells in an IL-10-dependent manner. A possible role of type 1-like regulatory cells in suppressing germinal center formation via secreting IL-10 is demonstrated. We observed that a "regulatory cell-based" tolerizing mechanism, rather than a "clonal deletion" mechanism, provides the possibility of reversing the tolerance by immunotherapeutic approaches.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- October 2013
- DOI:
- 10.1073/pnas.1306437110
- Bibcode:
- 2013PNAS..11016993X