Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era

We develop an improved method for predicting residue-residue contacts in protein structures that achieves higher accuracy than previous methods by integrating structural context and sequence coevolution information. We then determine the conditions under which these predicted contacts are likely to be useful for structure modeling and identify more than 400 protein families where these conditions are currently met.