We construct quantum models of two particles on a compact metric graph with singular two-particle interactions. The Hamiltonians are self-adjoint realizations of Laplacians acting on functions defined on pairs of edges in such a way that the interaction is provided by boundary conditions. In order to find such Hamiltonians closed and semi-bounded quadratic forms are constructed, from which the associated self-adjoint operators are extracted. We provide a general characterization of such operators and, furthermore, produce certain classes of examples. We then consider identical particles and project to the bosonic and fermionic subspaces. Finally, we show that the operators possess purely discrete spectra and that the eigenvalues are distributed following an appropriate Weyl asymptotic law.