Santilli's discoveries have attracted a large number of contributions by scientists from wide spectrum of countries. Santilli's dedicated efforts of 5-6 decades produced new mathematics that consists of iso-, geno-, hyper- and their isodual-branches . These new branches of new mathematics help him to remove long pending insufficiencies of various physical theories encompassing almost all branches of physics, chemistry and biology. That produced proper understanding of various natural and experimental physical phenomena; one of them that has been described in this paper is IsoRedShift. In 2009 the IsoRedShift (IRS) was first experimentally confirmed by Santilli in his IsoShift Testing Station. We have reviewed in brief Santilli's mathematical and physical conception of IsoRedShift (IRS) and the practical applications of IRS and IsoBlueShift (IBS).