We study the tunneling transport through a nanojunction in the far-from-equilibrium regime at relatively low temperatures. We show that the current-voltage characteristics is significantly modified as compared to the usual quasi-equilibrium result by lifting the suppression due to the Coulomb blockade. These effects are important in realistic nanojunctions. We study the high-impedance case in detail to explain the underlying physics and construct a more realistic theoretical model for the case of a metallic junction taking into account dynamic Coulomb interaction. This dynamic screening further reduces the effect of the Coulomb blockade.