Precise and programmable manipulation of microbubbles by two-dimensional standing surface acoustic waves
Abstract
A microfluidic device is developed to transport microbubbles (MBs) along a desired trajectory in fluid by introducing the phase-shift to a planar standing surface acoustic wave (SSAW). The radiation force of SSAW due to the acoustic pressure gradient modulated by a phase-shift can move MBs to anticipated potential wells in a programmable manner. The resolution of the transportation is approximately 2.2 µm and the estimated radiation force on the MBs is on the order of 10-9 N. This device can be used for manipulation of bioparticles, cell sorting, tissue engineering, and other biomedical applications.
- Publication:
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Applied Physics Letters
- Pub Date:
- April 2012
- DOI:
- Bibcode:
- 2012ApPhL.100q3701M
- Keywords:
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- bubbles;
- microfluidics;
- surface acoustic wave devices;
- 07.10.Cm;
- 85.85.+j;
- Micromechanical devices and systems;
- Micro- and nano-electromechanical systems and devices