The interaction between fluorobromomethane (CH2FBr) and titanium dioxide (TiO2) at room temperature has been investigated for the first time using Fourier-transform infrared spectroscopy. The obtained spectra show that the adsorption is possible by both the halogens. Moreover, CH2FBr interacts with TiO2 by H-bonds also. The first principles simulations on the possible adsorbate-substrate structures confirm that the adsorption can occur by both the F and Br atoms in the presence of one or two H-bonds. The interaction in the absence of H-bond is possible only in the case of Br halogen and it is associated with the lowest binding energy.