Mechanical properties of the aortic arterial wall during 24 hours: a preliminary study in conscious sheep
Abstract
Previous experiences in animals showed a different behavior between the variability of pressure, arterial diameter and elasticity when they were registered for a couple of hours. To better understand arterial mechanics variability, we propose to measure simultaneously aortic pressure and diameter during 24 hours in a sheep. For that purpose, we developed a portable prototype device. It allows continuously recording physiological signals throughout the day and storing them in a solid state memory for later analysis. Pulse wave velocity and Peterson modulus were assessed beat-to-beat as arterial stiffness indexes. We identified 53,762 heart beats during 24 hours that were separated into 2 groups: below or above median mean pressure (71 mmHg). Mean diameter, pulse wave velocity and Peterson modulus increased for higher pressure values (p<0.05) whereas heart rate slowed down (p<0.05). Pressure-diameter loops were successfully recreated all along the experience. This new methodology sets the basis for further experiences involving the estimation of 24 hours arterial mechanics variability.
- Publication:
-
Journal of Physics Conference Series
- Pub Date:
- December 2011
- DOI:
- 10.1088/1742-6596/332/1/012008
- Bibcode:
- 2011JPhCS.332a2008G