Coagulation dynamics of a blood sample by multiple scattering analysis
Abstract
We report a new technique to measure coagulation dynamics on whole-blood samples. The method relies on the analysis of the speckle figure resulting from a whole-blood sample mixed with coagulation reagent and introduced in a thin chamber illuminated with a coherent light. A dynamic study of the speckle reveals a typical behavior due to coagulation. We compare our measured coagulation times to a reference method obtained in a medical laboratory.
- Publication:
-
Journal of Biomedical Optics
- Pub Date:
- May 2011
- DOI:
- Bibcode:
- 2011JBO....16e7001F
- Keywords:
-
- biochemistry;
- biomedical measurement;
- bio-optics;
- blood;
- coagulation;
- enzymes;
- light scattering;
- molecular biophysics;
- speckle;
- 87.85.-d;
- 87.15.R-;
- Biomedical engineering;
- Reactions and kinetics