High-resolution structure of a retroviral protease folded as a monomer
Abstract
The crystal structure of Mason-Pfizer monkey virus protease folded as a monomer has been solved by molecular replacement using a model generated by players of the online game Foldit. The structure shows at high resolution the details of a retroviral protease folded as a monomer which can guide rational design of protease dimerization inhibitors as retroviral drugs.
- Publication:
-
Acta Crystallographica Section D
- Pub Date:
- October 2011
- DOI:
- Bibcode:
- 2011AcCrD..67..907G
- Keywords:
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- Mason–Pfizer monkey virus;
- HIV-1;
- retroviral proteases;
- retropepsins;
- protein folding;
- dimerization inhibition;
- drug-design targets;
- AIDS