A laser based reusable microjet injector for transdermal drug delivery
Abstract
A laser based needle-free liquid drug injection device has been developed. A laser beam is focused inside the liquid contained in the rubber chamber of microscale. The focused laser beam causes explosive bubble growth, and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle. The exit diameter of a nozzle is 125 μm and the injected microjet reaches an average velocity of 264 m/s. This device adds the time-varying feature of microjet to the current state of liquid injection for drug delivery.
- Publication:
-
Journal of Applied Physics
- Pub Date:
- May 2010
- DOI:
- 10.1063/1.3430989
- Bibcode:
- 2010JAP...107j3110H
- Keywords:
-
- drugs;
- jets;
- laser applications in medicine;
- laser beams;
- microfluidics;
- nozzles;
- optical focusing;
- 42.62.Be;
- 47.85.Np;
- 87.85.Ox;
- 85.85.+j;
- Biological and medical applications;
- Fluidics;
- Biomedical instrumentation and transducers including micro-electro-mechanical systems;
- Micro- and nano-electromechanical systems and devices