Therapeutic Ultrasound Enhancement of Drug Delivery to Soft Tissues
Abstract
Effects of exposure to 1.58 MHz focused ultrasound on transport of Evans Blue Dye (EBD) in soft tissues are investigated when an external pressure gradient is applied to induce convective flow through the tissue. The magnitude of the external pressure gradient is chosen to simulate conditions in brain parenchyma during convection-enhanced drug delivery (CED) to the brain. EBD uptake and transport are measured in equine brain, avian muscle and agarose brain-mimicking phantoms. Results show that ultrasound enhances EBD uptake and transport, and the greatest enhancement occurs when the external pressure gradient is applied. The results suggest that exposure of the brain parenchyma to ultrasound could enhance penetration of material infused into the brain during CED therapy.
- Publication:
-
8th International Symposium on Therapeutic Ultrasound
- Pub Date:
- April 2009
- DOI:
- 10.1063/1.3131459
- Bibcode:
- 2009AIPC.1113..403L
- Keywords:
-
- 43.35.Wa;
- 43.35.Ei;
- 43.80.Vj;
- Biological effects of ultrasound ultrasonic tomography;
- Acoustic cavitation in liquids;
- Acoustical medical instrumentation and measurement techniques