Lu5Ir4Si10 is an established charge-density-wave (CDW) compound (TCDW=83K) which undergoes superconducting transition (SC) at low temperatures (TC=3.9K) , leading to the coexistence of CDW and SC. On the other hand, Yb5Ir4Si10 is a Kondo lattice compound that shows possible CDW transition below 48K . In this study, we explore the influence of small Yb substitution for Lu in the series Lu5-xYbxIr4Si10 . Our observations indicate a decrease of both TCDW and TC with the increase of Yb content, with the evidence of a Kondo-like response below the CDW transition at low temperatures. Thus, one has a unique opportunity to study the Kondo effect in a CDW lattice in this system.